Nonlinear Model Predictive Control for Multi-Micro Aerial Vehicle Robust Collision Avoidance

Multiple multirotor Micro Aerial Vehicles sharing the same airspace require a reliable and robust collision avoidance technique. In this paper we address the problem of multi-MAV reactive collision avoidance. A model-based controller is employed to achieve simultaneously reference trajectory tracking and collision avoidance. Moreover, we also account for the uncertainty of the state estimator and the other agents position and velocity uncertainties to achieve a higher degree of robustness. The proposed approach is decentralized, does not require collision-free reference trajectory and accounts for the full MAV dynamics. We validated our approach in simulation and experimentally.Comment: Video available on: https://www.youtube.com/watch?v=Ot76i9p2ZZo&t=40

Model Predictive Control for Micro Aerial Vehicles: A Survey

This paper presents a review of the design and application of model predictive control strategies for Micro Aerial Vehicles and specifically multirotor configurations such as quadrotors. The diverse set of works in the domain is organized based on the control law being optimized over linear or nonlinear dynamics, the integration of state and input constraints, possible fault-tolerant design, if reinforcement learning methods have been utilized and if the controller refers to free-flight or other tasks such as physical interaction or load transportation. A selected set of comparison results are also presented and serve to provide insight for the selection between linear and nonlinear schemes, the tuning of the prediction horizon, the importance of disturbance observer-based offset-free tracking and the intrinsic robustness of such methods to parameter uncertainty. Furthermore, an overview of recent research trends on the combined application of modern deep reinforcement learning techniques and model predictive control for multirotor vehicles is presented. Finally, this review concludes with explicit discussion regarding selected open-source software packages that deliver off-the-shelf model predictive control functionality applicable to a wide variety of Micro Aerial Vehicle configurations

Voliro: An Omnidirectional Hexacopter With Tiltable Rotors

Extending the maneuverability of unmanned areal vehicles promises to yield a considerable increase in the areas in which these systems can be used. Some such applications are the performance of more complicated inspection tasks and the generation of complex uninterrupted movements of an attached camera. In this paper we address this challenge by presenting Voliro, a novel aerial platform that combines the advantages of existing multi-rotor systems with the agility of omnidirectionally controllable platforms. We propose the use of a hexacopter with tiltable rotors allowing the system to decouple the control of position and orientation. The contributions of this work involve the mechanical design as well as a controller with the corresponding allocation scheme. This work also discusses the design challenges involved when turning the concept of a hexacopter with tiltable rotors into an actual prototype. The agility of the system is demonstrated and evaluated in real- world experiments.Comment: Submitted to Robotics and Automation Magazin

RNA biomarkers in colorectal cancer

Colorectal cancer (CRC) develops and progresses through a systematic selection for (epi) genetic alterations that drive the transformation from normal colon epithelium to adenocarcinoma. These changes affect both noncoding RNAs and mRNAs and so define the clinical behaviour of cancer cells within a distinctive host genetic and environmental context. Although earlier diagnosis and more effective treatment modalities have decreased mortality from CRC, prognostic stratification and adjuvant therapy selection after surgery remain dependent on broad descriptive classifications, opportune histological markers of poor prognosis and chemotherapy efficacy data derived from diverse CRC populations. Crucially, there is significant inter- and intra-individual variability in response to, and tolerance of, chemotherapy treatments. These limitations explain the small clinical benefit of new agents studied in contemporary phase III trials. Molecular assays have the potential to address these constraints and there has been intense interest in the identification of clinically relevant molecular biomarkers. These must be easy to obtain and quantify and ideally represent steps in well-understood carcinogenic pathways or host-response mechanisms. Although some biomarkers can provide broad prognostic information based on CRC subtype (e.g. MSI status) or can somewhat predict response to targeted therapies (e.g. KRAS), no RNA-based biomarkers have entered routine clinical practice. This is due, in part, to the genetic heterogeneity of both patients and CRC. In addition, serious underlying issues with regards to study design, poor technical protocols, inadequate quality controls and inappropriate data analysis prevent successful translation of research results. Consequently, the identification of clinically relevant panels of biomarkers will depend not just on further advances in our understanding of CRC biology, but will need to be coupled with appropriate study designs and more suitable, standardised and transparent techniques

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe